All Dr. Hang Lin's publications


7. Li ZA, Sant S, Cho SK, Goodman SB, Bunnell BA, Tuan RS, Gold MS, Lin H. Synovial joint-on-a-chip for modeling arthritis: progress, pitfalls, and potential. Trends Biotechnol. 2022 Aug 19:S0167-7799(22)00193-7.

6. Li Z, Lin Z, Liu S, Yagi H, Zhang X, Yocum L, Romero-Lopez M, Rhee C, Makarcyzk MJ, Yu I, Li EN, Fritch MR, Gao Q, Goh KB, O'Donnell B, Hao T, Alexander PG, Mahadik B, Fisher JP, Goodman SB, Bunnell BA, Tuan RS, Lin H. Human Mesenchymal Stem Cell-Derived Miniature Joint System for Disease Modeling and Drug Testing. Adv Sci (Weinh). (2022; e2105909)

5. Xie M, Zhang Y, Xiong Z, Hines S, Shangjiang Y, Clark KL, Tan S, Alexander PG, Lin H. Generation of hyaline-like cartilage tissue from human mesenchymal stromal cells within the self-generated extracellular matrix. Acta Biomaterialia. (2022 Sep 1;149:150-166.)

4. He Y, Lipa K, Alexander PG, Clark KL, Lin H. Potential methods of targeting cellular aging hallmarks to reverse osteoarthritic phenotype of chondrocytes. Biology. (2022 Jun 30;11(7):996.)

3. Lin Z, Zhang X, Fritch, MR, Li Z, Kuang B, Alexander PG, Hao T, Cao G, Tan S, Bruce KK, Lin H. Engineering Pre-Vascularized Bone-like Tissue from Human Mesenchymal Stem Cells through Simulating Endochondral Ossification. Biomaterials, (2022; 283:121451)

2. Wang X, Guan Y, Xiang S, Clark KL, Alexander PG, Simonian LE, Deng Y, Lin H. Role of Canonical Wnt/β-Catenin Pathway in Regulating Chondrocytic Hypertrophy in Mesenchymal Stem Cell-Based Cartilage Tissue Engineering. Front. Cell Dev. Biol., (2022;812081)

1. Wang N, Zhang X, Rothrauff BB,  Z, Fritch MR, Chang A, He Y, Yeung M, Liu S, Lipa KE, Lei G, Alexander PG, Lin H. Novel Role of Estrogen Receptor-α on Regulating Chondrocyte Phenotype and Response to Mechanical Loading. Osteoarthritis and Cartilage. (2022;30(2):302-314)


10. Garcia-Ruiz A, Sánchez-Domínguez CN, Moncada-Saucedo NK, Pérez-Silos V, Lara-Arias J, Marino-Martínez IA, Camacho-Morales A, Romero-Diaz VJ, Peña-Martinez V, Ramos-Payán R, Castro-Govea Y, Tuan RS, Lin H, Fuentes-Mera L, Rivas-Estilla AM. Sequential growth factor exposure of human Ad-MSCs improves chondrogenic differentiation in an osteochondral biphasic implant. Exp Ther Med. (2021 Nov;22(5):1282.)

9. Li Z, Xiang S, Lin Z, Li Eileen, Yagi H, Cao G, Yocum L, Li L, Hao T, Bruce K, Fritch MR, Hu H, Wang B, Alexander PG, Khor K, Tuan RS, Lin H. Graphene oxide-functionalized nanocomposites promote osteogenesis of human mesenchymal stem cells via enhancement of BMP-SMAD1/5 signaling pathway. Biomaterials.  277 (2021) 121082

8. Gao Q, Li Z, Rhee C, Xiang S, Maruyama M, Huang EE, Yao Z, Bunnell BA, Tuan RS, Lin H, Gold MS, Goodman SB. Macrophages Modulate the Function of MSC- and iPSC-Derived Fibroblasts in the Presence of Polyethylene Particles. Int J Mol Sci. 2021 Nov 27;22(23):12837.

7. He Y, Yocum L, Alexander P, Jurczak M, Lin H. Urolithin A Protects Chondrocytes from Mechanical Overloading-Induced Injuries. Frontiers in Pharmacology. 2021;12:703847.

6. Xie M, Fritch M, He Y, Fu H, Hong Y, Lin H. Dynamic Loading Enhances Chondrogenesis of Human Chondrocytes within a Biodegradable Resilient Hydrogel. Biomaterials Science. 2021;9(14):5011-5024.

5. Wang N, He Y, Liu S, Makarcyzk M, Lei G, Chang A, Alexander P, Hao T, Padget A, Tsapekos M, de Pedro N, and Lin H. Engineering Osteoarthritic Cartilage Model through Differentiating Senescent Human Mesenchymal Stem Cells for Testing Disease-Modifying Drugs. SC Life Sciences.(Accepted).

4. Xiang S, Li Z, Fritch MR, Li L, Velankar S, Liu Y, Sohn J, Baker N, Lin H (corresponding author), Tuan RS. Caveolin-1 Mediates Soft Scaffold-enhanced Adipogenesis of Human Mesenchymal Stem Cells. Stem Cell Res Ther. 2021;12(1):347.

3. Huang Y, He Y, Makarczyk MJ, Lin H (corresponding author). Senolytic Peptide FOXO4-DRI selectively Removes Senescent Cells from in vitro Expanded Human Chondrocytes. Front. Bioeng. Biotechnol. 2021;9:677576. 

2. Shen H, He Y, Wang N, Fritch MR, Li X, Lin H (corresponding author), Tuan RS. Rejuvenation of Aged Human Articular Chondrocytes for High-quality Cartilage Regeneration. FASEB J. 2021;35(3):e21410.

1. Makarczyk MJ, Gao Q, He Y, Li Z, Gold MS, Hochberg MH, Bunnel BA, Tuan RS, Goodman SB, Lin H. Current Models for Development of Disease-Modifying Osteoarthritis Drugs. Tissue Engineering-C. (Cover story)2021;27(2):124-138.


11. He Y, Makarczyk MJ, Lin H (corresponding author). Role of Mitochondria in Mediating Chondrocyte Response to Mechanical Stimuli. Life Sciences. 2020;263:118602. 

10. Zhang X, Liu Y, Clark KL, Padget AM, Alexander PG, Dai J, Zhu W, Lin H (corresponding author). Mesenchymal stem cell-derived extracellular matrix (mECM): a bioactive and versatile scaffold for musculoskeletal tissue engineering. Biomedical Materials. 2020;16(1):012002.

9. Romero-López M, Li Z, Rhee C, Maruyama M, Pajarinen J, O'Donnell B, Lin TH, Lo CW, Hanlon J, Dubowitz R, Yao Z, Bunnell BA, Lin H, Tuan RS, Goodman SB. Macrophage Effects on Mesenchymal Stem Cell Osteogenesis in a Three-Dimensional In Vitro Bone Model. Tissue Engineering - Part A. 2020;26(19-20):1099-1111.

8. He Y, Li Z, Alexander PG, Ocasio-Nieves BD, Yocum L, Lin H (corresponding author), Tuan RS. Pathogenesis of Osteoarthritis: Risk Factors, Regulatory Pathways in Chondrocytes, and Experimental Models. Biology (Basel).2020;9(8):E194.

7. O'Donnell BT, Ives C, Al-Ghadban S, L'Ecuyer ML, Monjure TA, Romero-Lopez M, Li Z, Goodman SB, Lin H, Tuan RS, Bunnell BA. Adipose Tissue-Derived Stem Cells Retain their Adipocyte Differentiation Potential in 3-Dimensional Hydrogels and Bioreactors. Biomolecules2020;10(7):1070.

6. Li Z, Xiang S, Li NE, Fritch MR, Alexander PG, Lin H (corresponding author), Tuan RS. Tissue Engineering for Musculoskeletal Regeneration and Disease Modeling. Handbook of Experimental Pharmacology - Volume on Organotypic Models in Drug Development. 2020.

5. Sun K, Lin H (co-first author), Tang Y, Xiang S, Tan J, Tuan RS, Wang B. Injectable BMP-2 gene-activated scaffold for the repair of cranial bone defect in mice. Stem Cells Translational Medicine. 2020;9(12):1631-1642.  

4.Li L, Xiang S, Wang B, Lin H, Kihara S, Sun H, Alexander PG, Tuan RS. TGF-β1 plays a protective role in glucocorticoid-induced dystrophic calcification. Bone. 2020 Apr 4:115355.

3. Li H, Ding X, Terkeltaub R, Lin H, Zhang Y, Zhou B, He K, Li K, Liu Z, Wei J, Yang Y, Xie H, Zeng C, Lei G. Exploration of metformin as novel therapy for osteoarthritis: preventing cartilage degeneration and reducing pain behavior. Arthritis Res Ther. 2020 Feb 22;22(1):34.

2. Shen H, Lin H, Sun AX, Song S, Wang B, Yang Y, Dai J, Tuan RS. Acceleration of chondrogenic differentiation of human mesenchymal stem cells by sustained growth factor release in 3D graphene oxide incorporated hydrogels. Acta Biomater. 2020 105:44-55.

1. Li Z, Zhu W, Bi S, Li R, Hu H, Lin H, Tuan RS, Khor KA. Incorporating silica-coated graphene in bioceramic nanocomposites to simultaneously enhance mechanical and biological performance. J Biomed Mater Res A. 2020, 108(4):1016-1027.


11. Lin Z, Li E, Li X, Del Duke CJ, Shen H, Hao T, Bunnell BA, Goodman SB,Alexander PG, Tuan RS, Lin H (corresponding author). Osteochondral TissueChip Derived from iPSCs: Modeling OA Pathologies and Testing Drugs. Frontiers in Bioengineering and Biotechnology. 2019, 7:411.

10. Kuang B, Yang Y, Lin H(corresponding author). Infiltration and In-Tissue Polymerization of Photocross-Linked Hydrogel for Effective Fixation of Implants into Cartilage—An In Vitro Study. ACS Omega. 2019 4, 20, 18540-18544.

9. Yang Y, Liu Y, Lin Z, Shen He, Lucas C, Kuang B, Tuan RS, Lin H (corresponding author). Condensation-driven Chondrogenesis of Human Mesenchymal Stem Cells Within Their Own Extracellular Matrix: Formation of Cartilage with Low Hypertrophy and Physiologically Relevant Mechanical Properties. Advanced Biosystems. 2019 3(12):e1900229 (Front Cover).

8. Rothrauff BB, Sasaki H, Kihara S, Overholt KJ, Gottardi R, Lin H, Fu FH, Tuan RS, Alexander PG. Point-of-Care Procedure for Enhancement of Meniscal Healing in a Goat Model Utilizing Infrapatellar Fat Pad-Derived Stromal Vascular Fraction Cells Seeded in Photocrosslinkable Hydrogel. Am J Sports Med. 2019 Oct 23:363546519880468.

7.Li, Jiang Y, Lin H, Shen H, Sohn J, Alexander PG, Tuan RS. Muscle injury promotes heterotopic ossification by stimulating local bone morphogenetic protein-7 production. J Orthop Translat. 2019 Jul 5;18:142-153.

6. Lin H, Tang Y, Lozito TP, Oyster N, Wang B, Tuan RS. Efficient in vivo Bone Formation by BMP-2 Engineered Human Mesenchymal Stem Cells Encapsulated in a Projection Stereolithographically Fabricated Hydrogel Scaffold. Stem Cell Res Ther. 2019. 10(1):254.

5. Liu Y, Kuang B, Rothrauff BB, Tuan RS, Lin H (corresponding author). Robust bone regeneration through endochondral ossification of human mesenchymal stem cells within their own extracellular matrix. Biomaterials. 2019, Jul 6;218:119336.

4. Moncada-Saucedo NK, Marino-Martínez IA, Lara-Arias J, Romero-Díaz VJ, Camacho A, Valdés-Franco JA, Pérez-Silos V, García-Ruiz A, Lin H, Tuan RS, Ramos-Payán R, Lara-Banda M, Ortiz-Lopez R, Rojas-Martinez A, Fuentes-Mera L. A Bioactive Cartilage Graft of IGF1-Transduced Adipose Mesenchymal Stem Cells Embedded in an Alginate/Bovine Cartilage Matrix Tridimensional Scaffold. Stem Cells Int. 2019:9792369.

3. Lin H (corresponding author), Beck AM, Shimomura K, Sohn J, Fritch MR, Deng Y, Kilroy EJ, Tang Y, Alexander PG, Tuan RS. Optimization of Photocrosslinked Gelatin/Hyaluronic Acid Hybrid Scaffold for the repair of cartilage defect. J Tissue Eng Regen Med. 2019.

2. Deng Y, Lei G, Lin Z, Yang Y, Lin H (corresponding author), Tuan RS. Engineering hyaline cartilage from mesenchymal stem cells with low hypertrophy potential via modulation of culture conditions and Wnt/β-catenin pathway. Biomaterials. 2019, 192:569-578.

1. Deng Y, Sun AX, Overholt KJ, Yu GZ, Fritch MR, Alexander PG, Shen H, Tuan RS, Lin H (corresponding author). Enhancing chondrogenesis and mechanical strength retention in physiologically relevant hydrogels with incorporation of hyaluronic acid and direct loading of TGF-β. Acta Biomater. 2019, 83:167-176.


6. Vaudreuil N, Henrikson K, Pohl P, Lee A, Lin H, Olsen A, Dong Q, Dombrowski M, Kang J, Vo N, Lee J, Sowa G.Photopolymerizable biogel scaffold seeded with mesenchymal stem cells: safety and efficacy evaluation of novel treatment for intervertebral disc degeneration. J Orthop Res. 2018

5. Sasaki H, Rothrauff BB, Alexander PG, Lin H, Gottardi R, Fu FH, Tuan RS. In Vitro Repair of Meniscal Radial Tear With Hydrogels Seeded With Adipose Stem Cells and TGF-β3. Am J Sports Med. 2018, 46(10):2402-2413.''

4. Lin H, Sohn J, Langhans MT, Shen H, Tuan RS. Bone Marrow Mesenchymal Stem Cells: Aging and Tissue Engineering Applications to Enhance Bone Healing. Biomaterials, 2018, S0142-9612(18)30447-2.

3. Sohn J, Lin H, Fritch MR, Tuan RS. Influence of cholesterol/caveolin-1/caveolae homeostasis on membrane properties and substrate adhesion characteristics of adult human mesenchymal stem cells. Stem Cell Res Ther. 2018, 9:86.

2. Yang Y, Lin H (co-first author), Shen H, Wang B, Lei GH, Tuan RS. Mesenchymal Stem Cell-Derived Extracellular Matrix Enhances Chondrogenic Phenotype of and Cartilage Formation by Encapsulated Chondrocytes in vitro and in vivo. Acta Biomaterialia, 2018, 69:71-82.

1. Shen H, Lin H, Sun AS, Song SJ, Zhang ZJ, Dai JW, Tuan RS. Chondroinductive Factor-Free Chondrogenic Differentiation of Human Mesenchymal Stem Cells in Graphene Oxide- Incorporated Hydrogels. Journal of Materials Chemistry B, 2018, 6, 908 - 91.


5. Lin H, Tang Y, Lozito TP, Oyster N, Kang RB, Fritch MR, Wang B, Tuan RS. Projection Stereolithographic Fabrication of BMP-2 Gene-activated Matrix for Bone Tissue Engineering. Scientific Reports, 2017, 7, 11327.

4. Xue J, Lin H, Bean A, Tang Y, Tan J, Tuan RS, Wang B. One-Step Fabrication of Bone Morphogenetic Protein-2 Gene Activated, Porous Poly-L-Lactide Scaffold for Bone Induction. Molecular Therapy — Methods & Clinical Developments, 2017, 7, 50-59.

3. Sun AX, Lin H, Fritch MR, Shen H, Alexander PG, DeHart M, Tuan RS, Chondrogenesis of Human Bone Marrow Mesenchymal Stem Cells in 3- Dimensional, Photocrosslinked Hydrogel Constructs: Effect of Cell Seeding Density and Material Stiffness. Acta Biomaterialia, 2017, 58,302-11.

2. Blair HC, Larrouture QC, Li YN, Lin H, Beer-Stoltz D, Liu L, Tuan RS, Robinson LJ, Schelsinger PH, Nelson DJ . Osteoblast Differentiation and Bone Matrix Formation In Vivo and In Vitro. Tissue engineering-B, 2017, 23(3): 1-13.

1. Yang G, Rothrauff BB, Lin H, Gortardi R, Tuan RS. Tendon-Derived Extracellular Matrix Enhances TGF-β3 Induced Tenogenic Differentiation of Human Adipose- Derived Stem Cells. Tissue engineering-A, 2017, 23(3,4): 166-176.

Representative papers before 2017 (total 30)

Lin H, Lozito TP, Alexander PG, Gottardi R, Tuan RS. Stem Cell-based Microphysiological Osteochondral System to Model Tissue Response to Interleukin-1β. Molecular Pharmaceutics, 2014, 11(7):2203-12.

Lin H, Cheng AWM, Alexander P, Bech AM, Tuan RS. Cartilage Tissue Engineering Application of Injectable Gelatin Hydrogel with in situ Visible Light- Activated Gelation Capability in Both Air and Aqueous Solution. Tissue Engineering-A, 2014, 20 (17-18): 2402-11.

Lin H, Zhang DN, Alexander P, Yang G, Tan J, Cheng AWM, Tuan RS. Application of Visible Light-based Projection Stereolithography (VL-PSL) in Live Cell-Scaffold Fabrication with Designed Architecture. Biomaterials 2013, 34(2):331-9

Lin H, Yang G, Tan J, Tuan RS. Influence of Decellularized Matrix Derived from Human Mesenchymal Stem Cells on Their Proliferation, Migration and Multilineage Differentiation Potential. Biomaterials 2012, 33(18):4480-9.

Lin H, Zhao Y, Sun W, Chen B, Zhang J, Zhao W, Xiao Z, and Dai J. The effect of crosslinking heparin to demineralized bone matrix on mechanical strength and specific binding to human bone morphogenetic protein-2. Biomaterials, 2008,29:1189-1197.