Chondrocyte-based tissue engineering

Xie M, Fritch M, He Y, Fu H, Hong Y, Lin H. Dynamic Loading Enhances Chondrogenesis of Human Chondrocytes within a Biodegradable Resilient Hydrogel. Biomaterials Science. 2021;9(14):5011-5024.

Shen H, He Y, Wang N, Fritch MR, Li X, Lin H (corresponding author), Tuan RS. Rejuvenation of Aged Human Articular Chondrocytes for High-quality Cartilage Regeneration. FASEB J. 2021;35(3):e21410.

Huang Y, He Y, Makarczyk MJ, Lin H (corresponding author). Senolytic Peptide FOXO4-DRI selectively Removes Senescent Cells from in vitro Expanded Human Chondrocytes. Front. Bioeng. Biotechnol. 2021;9:677576. 

Kuang B, Yang Y, Lin H(corresponding author). Infiltration and In-Tissue Polymerization of Photocross-Linked Hydrogel for Effective Fixation of Implants into Cartilage—An In Vitro Study. ACS Omega. 2019 4, 20, 18540-18544.

Yang Y, Lin H (co-first author), Shen H, Wang B, Lei GH, Tuan RS. Mesenchymal Stem Cell-Derived Extracellular Matrix Enhances Chondrogenic Phenotype of and Cartilage Formation by Encapsulated Chondrocytes in vitro and in vivo. Acta Biomaterialia, 2018, 69:71-82.

Mesenchymal stem cell-based tissue engineering

 Xie M, Zhang Y, Xiong Z, Hines S, Shangjiang Y, Clark KL, Tan S, Alexander PG, Lin H. Generation of hyaline-like cartilage tissue from human mesenchymal stromal cells within the self-generated extracellular matrix. Acta Biomaterialia. (Accepted)

Li Z, Xiang S, Lin Z, Li Eileen, Yagi H, Cao G, Yocum L, Li L, Hao T, Bruce K, Fritch MR, Hu H, Wang B, Alexander PG, Khor K, Tuan RS, Lin H. Graphene oxide-functionalized nanocomposites promote osteogenesis of human mesenchymal stem cells via enhancement of BMP-SMAD1/5 signaling pathway. Biomaterials.  277 (2021) 121082

Lin Z, Zhang X, Fritch, MR, Li Z, Kuang B, Alexander PG, Hao T, Cao G, Tan S, Bruce KK, Lin H. Engineering Pre-Vascularized Bone-like Tissue from Human Mesenchymal Stem Cells through Simulating Endochondral Ossification. Biomaterials, (2022; 283:121451)

Xiang S, Li Z, Fritch MR, Li L, Velankar S, Liu Y, Sohn J, Baker N, Lin H (corresponding author), Tuan RS. Caveolin-1 Mediates Soft Scaffold-enhanced Adipogenesis of Human Mesenchymal Stem Cells. Stem Cell Res Ther. 2021;12(1):347.

Sun K, Lin H (co-first author), Tang Y, Xiang S, Tan J, Tuan RS, Wang B. Injectable BMP-2 gene-activated scaffold for the repair of cranial bone defect in mice. Stem Cells Translational Medicine. 2020;9(12):1631-1642

Liu Y, Kuang B, Rothrauff BB, Tuan RS, Lin H (corresponding author). Robust bone regeneration through endochondral ossification of human mesenchymal stem cells within their own extracellular matrix. Biomaterials. 2019, Jul 6;218:119336.

Deng Y, Lei G, Lin Z, Yang Y, Lin H (corresponding author), Tuan RS. Engineering hyaline cartilage from mesenchymal stem cells with low hypertrophy potential via modulation of culture conditions and Wnt/β-catenin pathway. Biomaterials. 2019, 192:569-578.

Lin H, Sohn J, Langhans MT, Shen H, Tuan RS. Bone Marrow Mesenchymal Stem Cells: Aging and Tissue Engineering Applications to Enhance Bone Healing. Biomaterials, 2018, S0142-9612(18)30447-2.

iPSC-based tissue engineering

 Lin Z, Li E, Li X, Del Duke CJ, Shen H, Hao T, Bunnell BA, Goodman SB,Alexander PG, Tuan RS, Lin H (corresponding author). Osteochondral TissueChip Derived from iPSCs: Modeling OA Pathologies and Testing Drugs. Frontiers in Bioengineering and Biotechnology. 2019, 7:411.

Cells combined with the self-generated extracellular matrix for tissue engineering

 Xie M, Zhang Y, Xiong Z, Hines S, Shangjiang Y, Clark KL, Tan S, Alexander PG, Lin H. Generation of hyaline-like cartilage tissue from human mesenchymal stromal cells within the self-generated extracellular matrix. Acta Biomaterialia. (Accepted)

Zhang X, Liu Y, Clark KL, Padget AM, Alexander PG, Dai J, Zhu W, Lin H (corresponding author). Mesenchymal stem cell-derived extracellular matrix (mECM): a bioactive and versatile scaffold for musculoskeletal tissue engineering. Biomedical Materials. 2020;16(1):012002.

Yang Y, Liu Y, Lin Z, Shen He, Lucas C, Kuang B, Tuan RS, Lin H (corresponding author). Condensation-driven Chondrogenesis of Human Mesenchymal Stem Cells Within Their Own Extracellular Matrix: Formation of Cartilage with Low Hypertrophy and Physiologically Relevant Mechanical Properties. Advanced Biosystems. 2019 3(12):e1900229 (Front Cover).

Liu Y, Kuang B, Rothrauff BB, Tuan RS, Lin H (corresponding author). Robust bone regeneration through endochondral ossification of human mesenchymal stem cells within their own extracellular matrix. Biomaterials. 2019, Jul 6;218:119336.

Yang Y, Lin H (co-first author), Shen H, Wang B, Lei GH, Tuan RS. Mesenchymal Stem Cell-Derived Extracellular Matrix Enhances Chondrogenic Phenotype of and Cartilage Formation by Encapsulated Chondrocytes in vitro and in vivo. Acta Biomaterialia, 2018, 69:71-82.